Developing improved cancer treatments is an ongoing struggle, and chemotherapy remains a cornerstone of many interventions. However, cancers are often resistant to chemotherapy. For example, drug-tolerant ‘persister’ cancer cells can cause disease relapse after therapy. The accumulation of iron in organelles called lysosomes is a hallmark of these persister cells1. Writing in Nature, Cañeque et al.2 present a way to exploit this vulnerability, using a small molecule to chemically activate the lysosomal iron and thereby drive lipid degradation, leading to a form of cell death called ferroptosis.

https://www.researchgate.net/publication/328635280_Syphilitic_Gumma_A_Rare_Form_of_Cutaneous_Tertiary_Syphilis