While most cell types experience a functional decline after years of proliferation and replication, T cells can proliferate seemingly indefinitely and without detriment. Scientists at St. Jude Children’s Research Hospital and the University of Minnesota investigated the unique ‘epigenetic clock’ of T-cell aging, demonstrating that T cells can outlive an organism through at least four lifetimes. In addition, the researchers showed that healthy T cell age was uncoupled from the organism’s chronologic age. Furthermore... Age is just a number: Immune cell ‘epigenetic clock’ ticks independently of organism lifespan - St. Jude Children’s Research Hospital (stjude.org)