Lyme disease, a bacterial infection caused by Borrelia burgdorferi, is typically associated with symptoms such as fever, headache, and a characteristic “bull’s-eye” rash. However, in some cases, the disease can progress to more severe neurological and psychiatric manifestations, including anxiety, depression, and even psychosis.

Proponents of the Lyme disease theory point to the fact that Mangione’s behavior was marked by intense anger, rage, and impulsive actions, which are not uncommon in individuals with untreated or undertreated Lyme disease. Some research suggests that the infection can trigger a range of cognitive and emotional disturbances, including mood swings, irritability, and even violent outbursts.

https://www.morgellonssurvey.org/anger-rage-obsession-and-impulsion-why-people-think-lyme-disease-is-a-factor-in-the-luigi-mangione-case/