The activity of the cannabis plant extracts, synthetic and endo-cannabinoids derivatives is well documented in eukaryotic systems. However, very few studies have been published on the effect of cannabinoids on microorganism (e.g. bacteria or fungi) and none on their effect on biofilm formation or on microbe's cell-cell communication (quorum sensing).

Biofilm is the most abundant state in which microbes are found in nature. Most infectious diseases are associated with biofilms. Quorum sensing has been shown to regulate virulence factors pathogenesis, motility and biofilm formation.

https://cannabinoids.huji.ac.il/effect-cannabis-cannabinoids-derivatives-biofilms