Men with endogenous testosterone levels lower than 213 ng/dL tended to have a higher risk of dying from any cause, according to an analysis of data from 11 studies involving more than 24 100 participants. Although testosterone levels vary by age, the cut-off for low testosterone concentrations is less than 300 ng/dL, based on the American Urological Association’s definition. Very low concentrations of testosterone—less than 153 ng/dL—were also associated with higher chance of dying from cardiovascular disease specifically. Meta-Analysis: Low Testosterone in Men Tied to Increased Risk of Death | Cardiology | JAMA | JAMA Network