Oct 03, 2025 7:51 am
Two distinct stem cell lineages that drive tooth root and alveolar bone formation have been identified by researchers from Science Tokyo. Using genetically modified mice and lineage-tracing techniques, the team has shed light on the cell signaling mechanisms guiding differentiation in stem cells in the developing teeth, offering key insights for future regenerative dental therapies.
The ability to regenerate lost teeth and their surrounding bones is considered a holy grail in the field of dentistry. For decades, the gold standard for replacing a lost tooth has been a foreign object, such as a dental implant or a denture. While these solutions are quite effective, they cannot perfectly replicate a natural tooth's structure, function, or feel. Many researchers are therefore conducting studies on tooth development to open new avenues for regenerative therapies.
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