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Jul 15, 2025 12:34 am
"Furthermore, differential expression analysis revealed that entropy-associated genes are enriched in developmental processes and depleted in metabolic pathways, indicating a possible link to cellular dedifferentiation. Finally, we found increased entropy in various age-related diseases beyond cancer, suggesting that transcriptomic disorder may be a common feature in age-related pathologies. Our findings establish transcriptomic entropy as a fundamental parameter in aging and cancer progression, offering new insights into disease mechanisms and challenging the current view that increased disorder is always detrimental."
https://www.biorxiv.org/content/10.1101/2025.06.29.662218v1
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