This open-label clinical trial examined the effects of a proprietary dietary supplement called Vascanox® HP on blood pressure and salivary nitric oxide levels in subjects with hypertension. The supplement contained a combination of dietary inorganic nitrate, S-allylcysteine (SAC), and other ingredients, such as vitamin C and polyphenols. The study found that Vascanox® HP effectively reduced both systolic and diastolic blood pressure in participants, particularly those with elevated diastolic blood pressure. This effect was attributed to the supplement's ability to increase nitric oxide (NO) bioavailability, which is essential for vasodilation. The trial also indicated that Vascanox® HP was safe and well-tolerated by the participants, suggesting its potential as a dietary supplement for controlling mild hypertension.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10578647/