Question  Is cytisinicline an effective and safe pharmacotherapy for smoking cessation and nicotine craving reduction?

Findings  In a replication randomized clinical trial of 792 adults who smoked 10 or more cigarettes daily and received behavioral support, both 6- and 12-week cytisinicline regimens were more effective than placebo, producing significantly higher continuous smoking abstinence rates than placebo at the end of drug treatment and through 24 weeks. Cytisinicline reduced nicotine cravings and was well tolerated.

Meaning  These results demonstrate the high smoking cessation efficacy and excellent tolerability of cytisinicline, confirm its ability to reduce nicotine craving, and support adoption of cytisinicline as a smoking cessation medication.

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2832701