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Nicotine improves working memory via augmenting BDNF levels through α7 nAChR: evidence from clinical and pre-clinical studies

Medicinal Nicotine

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Dr. Elijah

(@Dr. Elijah)

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Topic starter 07/01/2026 12:08 am

Introduction: While smoking has been associated with many negative consequences to human health, one possible benefit is that nicotine could improve cognitive functions. Previous studies have suggested that smoking may influence brain-derived neurotrophic factor (BDNF) levels. However, the exact effects of smoking on BDNF and cognition, and the potential neurobiological mechanisms underlying the changes induced by nicotine, remains elusive.

PUBMED.NCBI.NLM.NIH.GOV "https://pubmed.ncbi.nlm.nih.gov/40087918/"

Nicotine improves working memory via augmenting BDNF levels through α7 nAChR: evidence from clinical and pre-clinical studies

Our study unveils the critical role of nicotine in tobacco use affecting spatial memory. The mechanism by which this occurs involves the upregulation of BDNF expression, which is regulated by α 7 nAChR. These findings suggest that nicotine enhances spatial memory levels by enhancing endogenous BDNF …

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bdnf memory nicotine tobacco α 7 nachr

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