Even in the 21st century, malaria continues to be a major infectious disease in tropical and sub-tropical countries. Cerebral malaria, a complex and potentially reversible encephalopathy, is a severe complication of P. falciparum infection, which may lead to multi-organ failure and death. The mortality remains high even with the use of highly effective antimalarial drugs and intensive care management.

It is heartening that the World Health Organization (WHO) has recommended the widespread use of the RTS, S/AS01 (RTS,S) malaria vaccine among children in sub-Saharan Africa and in other regions with moderate-to-high P. falciparum malaria transmission. This recommendation has been based on results from ongoing pilot programs in Ghana, Kenya, and Malawi that have reached more than 900,000 children since 2019.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9192935/