Cognition360

The Future of Brain Health: Inflammation, Metabolism, and Cognitive Longevity

• Understand the role of neuroinflammation and metabolic dysfunction in the progression of cognitive decline
• Examine the gut-brain axis as a modifiable driver of neurodegenerative risk
• Identify evidence-based lifestyle interventions for preventing cognitive decline and enhancing brain resilience
• Discuss the impact of modern diets, sedentary behavior, and environmental triggers on brain aging.

David Perlmutter, MD

The Gut, Brain, and Barriers: Protecting Cognitive Function

• Introduce the endothelial glycocalyx as a key factor in the maintenance of blood-brain barrier integrity and the implications for the brain inflammatory cascade, including activation of Amyloid and Tau proteins.
• Discuss the role of gut-barrier integrity in the Gut-Brain axis
• Review the pathological processes involved in the development of Alzheimer’s Disease.
• Learn about emerging brain health markers that can help to identify early changes and risk of progression to allow earlier intervention.

Kristine Burke, MD

Break

Neuroplasticity & Brain Regeneration: What’s Possible?

• Mechanisms that drive neuroplasticity
• Nutrition, lifestyle, and electrical stimulation as regenerative tools
• Wahls Protocol and MS patient outcomes as clinical models
• Resilience, repair, and functional recovery in aging brains

Terry Wahls, MD

Quantum Wellness:  A New Frontier in Cognitive and Cellular Longevity Backed by University Studies Published in Peer-Reviewed Journals (Non-CME)
Ashley Grace

Lunch

Functional Medicine Approaches to Cognitive Decline

• Explore functional medicine protocols for preventing cognitive decline.
• Identify root causes of neurodegenerative conditions.
• Implement personalized interventions for brain health optimization.

Kristine Burke, MD

Mitochondria & Cognitive Aging: Bioenergetics for Brain Health

• Discuss the role of mitochondrial function in cognitive health.
• Analyze how bioenergetic deficits contribute to neurodegeneration.
• Evaluate therapeutic strategies to optimize mitochondrial performance.

Dayan Goodenowe, PhD

Break

The Science of Stress: The Hidden Driver of Cognitive Decline

• Explain the physiological impact of chronic stress on the brain, including neuroinflammation, oxidative stress, and neurotransmitter imbalances.
• Analyze the connection between the HPA axis, cortisol dysregulation, and cognitive function in aging populations.
• Identify key biomarkers and diagnostic tools to assess stress-related cognitive decline.
• Review evidence-based strategies including botanicals, adaptogens, peptides, and lifestyle interventions to mitigate the effects of stress on cognition.
• Discuss the role of gut health and the microbiome in modulating stress response and neurodegeneration.

Ashok Gupta, MD

Immunometabolic Engines of Brain Health and the Emerging Role of Phytochemicals
Austin Perlmutter, MD

Close of Session