Peripheral-Microbiome Signaling in Pain and Neurodegeneration: A Multimodal Treatment Framework with David G. Changaris, MD

Learning Objectives
Upon completion of this activity, participants will be able to:
• Explain the role of dermal microbiome density in driving chronic pain, inflammation, and neurodegenerative cascades through TRPV-1 receptor activation and retrograde axonal transport
• Describe the mechanisms by which peripheral microbiome signaling (quorum sensing molecules, biofilm metabolites) initiates central neuroinflammation and neurodegeneration
• Apply multimodal transdermal treatment strategies that synergistically target peripheral microbiome signaling to address chronic pain and neurological conditions