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Article courtesy of Dr. Joel Kahn, MD, who is a Clinical Professor of Medicine at Wayne State University School of Medicine, one of the world’s top cardiologists, a best-selling author, lecturer, and a leading expert in plant-based nutrition and holistic care. Although heart disease impacts many more people than Alzheimer’s Dementia (AD), people fear AD …
Could measuring protein clumps in our cells be a new way to find out our risk of getting age-related diseases? Professor Dorothee Dormann and Professor Edward Lemke of Johannes Gutenberg University Mainz (JGU), who are also adjunct directors at the Institute of Molecular Biology (IMB) in Mainz, propose the concept of a “protein aggregation clock” …
Researchers from Queen Mary University of London report in Nature Mental Health developing a method for predicting dementia with over 80% accuracy, up to nine years before a diagnosis, and is suggested to be a more accurate way to predict dementia than memory tests or measuring brain shrinkage. “Predicting who is going to get dementia …
Engineers at the University of California San Diego have discovered that some brain cells age more rapidly than others, and they are disproportionately abundant in individuals afflicted with Alzheimer’s disease. Additionally, researchers observed sex-specific differences in the aging process of certain brain cells, with the female cortex exhibiting a higher ratio of “old” oligodendrocytes to …
It has long been known that a hallmark of Alzheimer’s disease, and most other neurodegenerative diseases, is the clumping together of insoluble protein aggregates in the brain. During normal disease-free aging, there is also an accumulation of insoluble proteins. To date, approaches to treatments for Alzheimer’s disease have not addressed the contribution of protein insolubility …
Research Highlights At a Glance: People with two copies of a certain gene, APOE4, predictably developed Alzheimer’s disease from the relatively early age of 55 years. The findings suggest a newly defined genetic form of Alzheimer’s disease, with implications for future research, diagnosis, and treatment. A small portion of early-onset Alzheimer’s disease (AD) cases are …
Proteins are the workhorses of life. Organisms use them as building blocks, receptors, processors, couriers and catalysts. A protein’s structure is critical to its function. Malformed proteins not only fail to carry out their tasks, they can accumulate and eventually gum up the inner workings of cells. As a result, misfolded proteins cause a variety …
Alzheimer’s disease (AD) currently afflicts nearly seven million people in the U.S. With this number expected to grow to nearly 13 million by 2050, the lack of meaningful therapies represents a major unmet medical need. Scientists at Sanford Burnham Prebys have now identified promising real-world links between common HIV drugs and a reduced incidence of …
A smartphone app could enable greater participation in clinical trials for people with frontotemporal dementia (FTD), a devastating neurological disorder that often manifests in midlife. Research into the condition has been hampered by problems with early diagnosis and difficulty tracking how people are responding to treatments that are only likely to be effective at the …
Columbia researchers have discovered a genetic variant that reduces the odds of developing Alzheimer’s disease by up to 70% and may be protecting thousands of people in the United States from the disease. The discovery of the protective variant, which appears to allow toxic forms of amyloid out of the brain and through the blood-brain barrier, …