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Researchers from Georgetown University were investigating a protein for cancer studies which turned out to be a powerful metabolism regulator, as published in Scientific Reports. Forced expression of FGFBP3 in obese mice showed significant reduction of their fat mass despite being genetically predispositioned to eat all the time, suggesting this may offer a novel therapy …
New roles for BP3 have been shown for regulating carbohydrate and lipid metabolism that overlaps effects of endocrine FGF19 and FGF21; BP1 and BP3 proteins share cysteine residues but have distinct C terminal FGF binding domains, as published in Scientific Reports. Fibroblast growth factor binding protein 3 binds to FGF19, FGF21, and FGF23; interaction between …