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cardiomyocyte

Age-Related Decline In 2 Sirtuin Enzymes Alters Mitochondrial Dynamics, Weakens Cardiac Contractions

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PARKINSON’S, CANCER, TYPE 2 DIABETES SHARE A KEY ELEMENT THAT DRIVES DISEASE

Sirtuins are a family of anti-aging proteins that help regulate cellular lifespan, metabolism, and resistance to stress. The potential protective effect of these sirtuin enzymes in age-related diseases, including cardiovascular diseases, remains an area of intense investigation. Now, a new preclinical study led by University of South Florida Health (USF Health) researchers has determined that …

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‘An incredible discovery’: Researchers ID a gene that regenerates damaged muscles after a heart attack

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Whole Slide Digital Imaging

Although humans show minimal regenerative capability, zebrafish can regenerate their hearts through a mechanism whereby heart muscle cells (cardiomyocytes) revert to a less mature state and then proliferate to replace the damaged tissue. Ogawa et al. show that Krüppel-like factor 1 (Klf1/Eklf), a transcription factor well known for its role in red blood cell development, …

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