Epigenetic Modulation Of Chronic Anxiety & Pain By Histone Deacetylation
Prolonged exposure of the central amygdala to elevated corticosteroids facilitates long term anxiety and pain through activation of glucocorticoid receptors and corticotropin releasing factors, but the underpinning mechanisms maintaining the responses are not known. Chronic phenotypes can be sustained by epigenetic mechanisms including histone modifications such as deacetylation. In this study which is published in …