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Experimental ‘gene silencing’ therapy reduces lipoprotein(a), an important risk factor of heart disease, by up to 98%

Anti-Aging & Longevity Genetic Discoveries

Findings from a new Cleveland Clinic-led phase 1 trial show that an experimental “gene silencing” therapy reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 98%. Findings from the “APOLLO Trial: Magnitude and Duration of Effects of a Short-interfering RNA Targeting Lipoprotein(a): A Placebo-controlled Double-blind Dose-ranging Trial” were presented …

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Delivering RNA therapies to brain tumors

Delivering RNA therapies to brain tumors

A combination of nanoparticle packaging and focused ultrasound allowed an RNA therapy to be delivered across the blood-brain barrier in mice. Brain tumors in mice treated using the combination experienced substantial cell death, suggesting its feasibility as a brain cancer therapy Ribonucleic acid, better known as RNA, is a workhorse molecule in the body. Different …

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