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Image Caption: An illustration of a brain cell in a person with Alzheimer’s disease, showing the accumulation and clumping of tau proteins (blue squiggles) in the cytoplasm of brain cells. Protein clumps, also known as aggregates, are thought to lead to cell death and dementia. New research suggests that such clumps may not cause brain …
A gene encoding a protein linked to tau production — tripartite motif protein 11 (TRIM11) — was found to suppress deterioration in small animal models of neurodegenerative diseases similar to Alzheimer’s disease (AD), while improving cognitive and motor abilities, according to new research from the Perelman School of Medicine at the University of Pennsylvania. Additionally, …
Short cycles of a low-calorie diet that replicates fasting appeared to reduce inflammation and delay cognitive decline in mouse models of Alzheimer’s disease; initial data indicates diet’s safety in Alzheimer’s patients. The study appeared in Cell Reports on Sept. 27. 2022. Cycles of a diet that mimics fasting appears to reduce signs of Alzheimer’s in …
Alzheimer’s disease, the most common form of dementia, currently has no cure or effective therapy, in part due to gaps in our understanding of how the progressive neurodegenerative disorder arises in the brain. Now, a Flinders University study has shown how a protein called tau, a critical factor in the development of Alzheimer’s disease, turns …
Neurodegenerative diseases like Alzheimer’s and Parkinson’s are defined by the pathogenic accumulation of toxic proteins in the brain. Now, however, scientists from the National Institutes for Quantum Science and Technology have established that the p62 protein, which is involved in cellular protein degradation, can prevent the accumulation of toxic oligomeric tau species in mouse brains, …
It’s often said that a little stress can be good for you. Now scientists have shown that the same may be true for cells, uncovering a newly-discovered mechanism that might help prevent the build-up of tangles of proteins commonly seen in dementia. A characteristic of diseases such as Alzheimer’s and Parkinson’s — collectively known as …
Image: Tau tangles in the brains of mice with FNSS genes. The FNSS genes appear to protect from the accumulation of tau protein (green). Image credit: Fu Lab – UC San Francisco ‘Elite Sleeper’ Genes Could Offer Protection from Neurodegenerative Diseases Some people are gifted with genes that pack the benefits of slumber into an …
Utilizing cutting-edge proteomics, researchers at the Buck Institute and elsewhere have mapped the “tau interactome” uncovering new findings about the role of tau in neurodegenerative disease. Publishing in Cell, scientists found that mutant tau impacts the function of mitochondria in human neurons. They also suggest a mechanism for how tau gets released from neurons and …
When elderly people stay active, their brains have more of a class of proteins that enhances the connections between neurons to maintain healthy cognition, a UC San Francisco study has found. This protective impact was found even in people whose brains at autopsy were riddled with toxic proteins associated with Alzheimer’s and other neurodegenerative diseases. …
Via drug repositioning, Osaka City University creates a combination of rifampicin and resveratrol and have shown in mouse models that nasal administration improves cognitive function without the negative liver side effects of rifampicin alone. Researchers from Osaka City University have shown in mice models of Alzheimer’s disease, frontotemporal dementia, and dementia with Lewy bodies, that …